What is Epithalon?
Epithalon, also known as Epitalon, is a four amino acid long peptide that has been suggested by researchers to potentially supplement protein production that has a direct mitigating impact on age-related decline and potentially also in mitigating cancer cell proliferation. Numerous studies on murine models have allowed researchers to hypothesize on the peptide’s possible mechanism of action and breadth of impact. Because of the short size of the Epithalon, researchers consider the possibility that the peptide may enter the cell membrane without the help of transporters and may thereby make its way to the nucleus of cells. This is of utmost importance, as once it is in the nucleus, Epithalon may theoretically effect the regulation of genes, activating some and deactivating others to induce cell-wide downstream changes.
Previous research studies have posited that Epithalon may exhibit the potential to stimulate immune system functioning, which may see a natural arc of decline over time. Investigation of the mechanism of this action uncovered the potential of Epithalon to interact with the promoter region of the interferon-gamma gene. By promoting interferon-gamma production, a key immune regulator, Epithalon may potentially boost T cells’ functioning and support immunity.
The idea that short peptides might affect the DNA-level processes has caused a boom in the scientific community, and research of Epithalon and other short peptides in animal models has seen an uptick in broad research. Such investigations have formulated a theory that Epithalon may possibly impact epidermal aging by activating the cellular repair processes, which often enter the dormant phase with age.
Epithalon Peptide and Skin Aging
Research by scientists in Russia has posited the theory that Epithalon may potentially activate skin fibroblasts, the cells responsible for repairing and maintaining the extracellular matrix that strengthens skin. Collagen, elastin, and other skin proteins can be found in the extracellular matrix in the skin. Research studies in rats have suggested that Epithalon may activate fibroblasts to the extent of up to 30-45%, though these studies continue to be conducted.
Epithalon is considered a unique molecule, particularly when exposed to the skin surface, as the peptide may potentially penetrate the skin barrier to ender cells and stimulate the growth and development of fibroblasts, which secrete impactful proteins like collagen. This may produce a significantly potent impact, leading to skin cell regeneration at multiple levels, but this hypothesis requires further scientific investigation.
The epidermal layer becomes brittle over time, prone to lesions and small tears, and often subjected to chronic insults that lead to pressure ulcers, diabetic ulcers, and other afflictions. The potential of supporting epidermal structure with increased protein production may contribute to the strength and efficacy of the skin barrier, and potentially mitigate instances of damage, disease, or infection.
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