What are Growth Hormone Secretagogues?

Growth Hormone secretagogues are a group of substances that induce the release of Growth Hormone. These include the agonists of Growth Hormone/Ghrelin secretagogue hormone receptors (Ghrelin, GHRP-2, GHRP-6) and Growth Hormone-releasing hormone receptors (CJC-1295, Growth Hormone releasing hormone).

Growth Hormone Releasing Peptides (GHRPs) are different from GHRH structurally but perform a similar function. The hypothalamus secretes Growth Hormone-Releasing Hormone. As discussed later, it acts on the pituitary gland and stimulates the production of Growth Hormone, which has numerous benefits in the body.

GHRP is a synthetic compound that works on specific receptors in the pituitary and hypothalamus. This action ultimately increases the release of growth hormones. GHRPs block the effect of the inhibitory hormone (Somatostatin) that prevents the production of Growth Hormone.

What is Growth Hormone Releasing Peptide (GHRP-2)?

GHRP-2 is also known as Pralmorelin or KP-102. It is a second-generation non-glycosylated hexapeptide. It is the first GHRPs to be introduced in clinical experiments. The administration of GHRP-2 peptide markedly increases the Growth Hormone level in the blood. It also acts as an agonist of the Ghrelin receptors and leads to increased hunger and faster stomach emptying.

GHRP-2 peptide is closely related to GHRP-6 and shares many properties. However, the ability of GHRP-2 peptides to increase the levels of growth hormone is far more potent than that of GHRP-2. A study performed on cultured pituitary cells demonstrated an increase in the portion of Growth hormone to as much as ten fold in response to GHRP-2 peptide.

Mechanism of Action of GHRP-2

GRHP-2 stimulates the release of Growth Hormone by a Ca+2 dependent pathway. It mimics Ghrelin by enhancing appetite and stomach emptying. It can also increase the level of growth hormone by a two-fold mechanism. It implies that in addition to stimulating the release of more Growth Hormone, it inhibits the impact of Somatostatin (SRIF).

Somatostatin is a hormone that antagonizes the natural release of Growth hormone via a GHRH-mediated mechanism. These increased growth hormone levels in the body can produce desired benefits. GRHP-2 increases the secretion of GH while causing only a mild stimulatory effect on adrenocorticotrophic hormone (ACTH), Prolactin, and Cortisol levels. This action ensures the desired benefits of Growth Hormone minus the side effects associated with other Growth hormone secretagogues.

Research Implications Of GHRP-2

GHRP-2 peptide has been studied widely for its utility as a secretagogue for Growth Hormones. It naturally increases the production of Growth Hormone. Researchers investigated its use in treating pituitary dwarfism (short stature due to growth hormone deficiency at an early age).

This experiment had reached stage two of clinical trials; however, its implications in the treatment never emerged on the market because the increase in the plasma levels of Growth hormone was significantly lower in the patients with Growth hormone disease than healthy individuals. GRHP-2 can also be of use as a diagnostic agent for cases of Growth Hormone deficiency.

Studies carried out on animal subjects have demonstrated the following benefits of the use of GHRP-2 peptide:
● GHRP-2 peptide promotes muscle growth and increases lean muscle mass. It stimulates hypertrophy and hyperplasia of the myoblasts (Muscle cells). These effects can lead to better performance and strength.
● The use of GHRP-2 decreases inflammation of the liver.
● GHRP-2 peptide speeds up the rate of healing and repair following an injury. It improves the overall regenerative ability of the body. Researchers can use these effects in a variety of cosmetic procedures.
● GHRP-2 helps reduce the risk of cardiovascular diseases. It improves insulin resistance and provides better glycemic control. It also promotes triglyceride breakdown and lowers the risk of cardiovascular accidents.
● The use of GHRP-2 peptide offers some degree of pain relief.
● Strengthens the immune system.
● GHRP-2 peptide improves vitality and enhances freshness throughout the day.
● Slows down the aging process and helps maintain healthy-looking skin.
● Promotes collagen synthesis and has rejuvenating effects on the body.
● Reduces body fat by promoting lipolysis.
● Builds and strengthens healthy tissue in the brain, lungs, and kidneys.
● Improves bone mineral density in children and helps in age-related degenerative diseases of bones such as osteoporosis.
● Improves sleep and increases alertness and clarity of mind.
● Improves health in neurodegenerative conditions such as Parkinson’s and Alzheimer’s.

GHRP-2 peptide acts physiologically to increase plasma levels of Growth Hormone in the body with minimal side effects. The use of this peptide can prove to be a groundbreaking tool in ameliorating age-related problems.

 


 

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