Cardiogen (20mg)

$60.00

Size: 20mg
Contents: Cardiogen (20mg)
Form: Lyophilized powder
Purity: >99%
SKU: P-cardiogen
Availability: In Stock

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Description

Cardiogen is a peptide bioregulator that affects fibroblasts, causing scar formation and tissue repair throughout the body. The peptide is known for its impact on cardiovascular disease, but recent research has shown that it is also functional in other body tissues by influencing fibroblast activities. These activities include supporting and connecting to other body tissues or organs, secreting collagen proteins, maintaining structural tissue skeletons, healing wounds, and more.

Furthermore, scientists believe Cardiogen is synergistic and can work with standard therapies to improve outcomes while reducing side effects. Additional research in mouse models shows that the peptide increases tumor cell apoptosis.

The Structural Properties of Cardiogen[1]

Molecular Formula: C18H31N7O9

Molecular Weight: 489.5 g/mol

PubChem CID: 11583989

Synonyms: SCHEMBL3194515

IUPAC Condensed: H-Ala-Glu-Asp-Arg-OH

The Clinical Importance of Cardiogen

This peptide has been shown to have anticancer effects, including increased cardiomyocyte proliferation, reduced scar formation and rapid cardiac remodeling in a failing heart, prevention and progressive control of prostate cancer, and other clinical benefits.

The Anticancer Effect of Cardiogen

Cardiogen is an excellent apoptotic reductant in cardiac cells by decreasing p53 expression and may exhibit opposite impacts on tumor cells. The p53 gene produces a protein found inside the nucleus of cells and is essential in controlling cell division and cell death. An experiment was conducted on mice with M-1 Sarcoma (indicating it has metastasized to other body tissues and organs) to determine the tumor-modulating effects of Cardiogen, which showed that apoptosis on tumor cells exceeded normal levels and was uncontrollable.[2] This result is also a consequence of necrotic and hemorrhagic development and the improvement of tumor cell apoptosis.

The results of the experiment showed that:

The dose-dependent inhibition of M-1 sarcoma growth after injection of cardiogen was caused by the development of hemorrhagic necrosis and stimulation of tumor cell apoptosis. The parameters of proliferative activity indicate that inhibition of tumor growth was not caused by the direct cytostatic effect of the drug on the tumor. Morphological signs indicate a specific mechanism of cardiogen action, realized through the vascular network of the tumor’. [2]

The proliferative action of the peptide demonstrates that tumor growth inhibition is not the result of a cytostatic drug’s direct effect on the tumor. According to morphology, tumor growth inhibition may be mediated by a specific peptide mechanism of action. This event may be particular to some tumor cells due to their atypical and increased vascular supply, demonstrating that Cardiogen can be a valuable adjunct in the fight against cancer. Cardiogen’s ability to positively influence standard cancer treatments is still being studied. 

Cardiogen’s Protective and Progressive Control against Prostate Cancer

According to research, Cardiogen and other peptides can significantly increase the expression of signaling factors involved in the differentiation of human prostate fibroblasts while decreasing synthesis in senescent cultures.[3] Because these signaling factors promote the development and progression of prostate cancer, they can be inhibited in aging and senescent fibroblasts. This inhibition explains why prostate cancer is common in the elderly but rarely found in the young. Here, Cardiogen actively influences the signaling factors, bringing them to normal levels or better than those seen in young cell cultures.

The Impact of Cardiogen on Cardiomyocytes

Different peptides have been shown to be effective in various cardiovascular conditions.[4] Cardiogen is a potent cardiac peptide that can increase cardiomyocyte proliferation while decreasing fibroblast growth and development and scar formation, resulting in long-term and improved cardiac remodeling with the potential to cause congestive cardiac failure.

Studies show that Cardiogen can reduce the expression of the p53 gene, resulting in a lower apoptosis rate.[5] Cardiogen can treat heart failure, hypertension, angina pectoris attacks, myocardial hypertrophy, myocardiodystrophy, myocarditis, and coronary heart disease in the elderly. Cardiogen can also help athletes, divers, submariners, and others who maintain stamina under heavy pressure and adverse environmental conditions. Following the treatment and prevention of cardiovascular diseases with Cardiogen, patients can achieve longevity and reduced risks of heart muscle pathologies.

Cardiogen promotes cardiomyocyte proliferation as suggested by research:

The tetrapeptide cardiogen demonstrated the great stimulating effect on the proliferation both in tissues from young and old rats. The immunohistochemical study demonstrated a decrease of the p53 protein expression by cardiogen action. This fact can testify that cardiogen inhibits the apoptosis process in the myocardial tissue’.[5] 

Summary

Cardiogen appears to be the least researched of the numerous bioregulators, despite having enormously powerful effects on various body tissues such as the heart and prostate. Cardiogen is effective in treating certain types of cancer, such as Sarcoma. Cardiogen supplementation and administration are most common and vital in heart attacks, chronic heart failure, hypertension, coronary heart diseases, myocarditis, angina pectoris attacks, and other conditions. 

This peptide has minimal or no side effects in mice, with excellent oral and unrivaled subcutaneous bioavailability.

Cardiogen is available for educational and scientific purposes, not for human consumption. Only purchase Cardiogen if you are a licensed researcher.

References

  1. https://pubchem.ncbi.nlm.nih.gov/compound/Cardiogen-82 
  2. Levdik NV, Knyazkin IV. Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats. Bull Exp Biol Med. 2009 Sep;148(3):433-6. English, Russian
  3. Kheĭfets OV, Poliakova VO, Kvetnoĭ IM. [Peptidergic regulation of the expression of signal factors of fibroblast differentiation in the human prostate gland in cell aging]. Adv Gerontol. 2010;23(1):68-70
  4. Grieco P, Gomez-Monterrey I. Natural and synthetic peptides in the cardiovascular diseases: An update on diagnostic and therapeutic potentials. Arch Biochem Biophys. 2019 Feb 15;662:15-32. doi: 10.1016/j.abb.2018.11.021
  5. N. I. Chalisova et al., “[The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats],” Adv. Gerontol. Uspekhi Gerontol., vol. 22, no. 3, pp. 409–413, 2009

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