Chonluten (20mg)

$61.00

Size: 20mg
Contents: Chonluten (20mg)
Form: Lyophilized powder
Purity: >99%
SKU: P-Chonluten
Availability: In Stock

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Description

​Chonluten, also known as EDG tripeptide, contains a natural peptide complex that restores normal physiological processes of the respiratory pathway by reinforcing the synthesis of proteins. It regulates mechanisms of anabolism and catabolism, pivotal to overall health and wellbeing.

Chonluten is a peptide complex containing glycine, glutamine, and asparagine, which normalizes the performance of bronchial mucous membrane cells.

Chonluten has saved numerous lives by balancing significant proliferative activity. It is a preventative treatment for people susceptible to respiratory problems and combats various additional respiratory health issues.[1] Primarily, Chonluten’s function is to normalize the effect on target organs by replacing or supporting the activity of substances secreted by these morphological structures through immunomodulation. It also increases the lifespan of mesenchymal stem cells (MCS) and induces molecular mechanisms that contrast senescence.

Chonluten is organ-specific, being most influential in lung tissues, and extends action in the gastrointestinal tract. Its effectiveness manifests in treating asthma, Chronic Obstructive Pulmonary Disease (COPD), and other diseases affecting the stomach lining.[2]

Chonluten revitalizes, regulates, and provides premium refurbishment to the airway and bronchial mucosa.

The Structural Properties of Chonluten[3]

Molecular Formula: C11H17N308

Molecular Weight: 319.27

PubChem CID: 194641

Synonyms: Glu-asp-gly, Glutamyl-aspartyl-glycine, H-Glu-asp-gly-OH, T-34 tripeptie

Cas No: 75007-24-8

IUPAC Condensed: 4S)-4-amino-5-[[(2S)-3-carboxy-1-(carboxymethyl amino)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid

XlogP3-AA: -5.3

Hydrogen Bond (donor count): 6

Hydrogen Bond (acceptor count): 9

Rotatable Bond: 10

Topological Polar Surface: 196 Ų

Heavy Atom Count: 22

Exact Mass: 319.10156451

Complexity: 464

Uses of Chonluten

 

Geroprotectors of Lungs and GI Tract

As the lung capacity reduces with age, Chonluten decreases the rate of cell death while encouraging proliferative activity. 

Chronic conditions such as bronchitis and COPD can lead to progressive respiratory system failure. Chonluten helps restore respiratory systems and also relieves chest trauma. Chonluten facilitates recovery in asthma, smoker’s cough, pulmonary tuberculosis, and pneumonia.[2]

The bronchial inner lining is a barrier between the external environment from which we breathe and our internal structures. Different inflammatory diseases can affect this inner lining, such as COPD and asthma, and can change mucus production and extracellular matrix structure, and cause other adverse effects. Smoker’s cough is an inflammatory disease that causes chronic irritation of the mucosal lining and phlegm production, chronic cough, and other symptoms. Chonluten’s mechanisms of action help to alleviate these inflammatory conditions.

Chonluten’s impact on the GI tract is similar to that in the lungs as it reduces inflammation while preventing the prevalence of vascular changes that induce inflammatory diseases, such as ulcerative colitis and Crohn’s disease. Notably, Chonluten research in this context is still underway.

Regulation of Gene Expression

Short peptides, such as Chonluten, regulate all aspects of DNA expression, such as DNA methylation.[4, 5]

Research suggests that:

Short peptides, consisting of 2-7 amino acid residues, can penetrate into the nuclei and nucleoli of cells and interact with the nucleosome, the histone proteins, and both single- and double-stranded DNA. DNA-peptide interactions, including sequence recognition in gene promoters, are important for template-directed synthetic reactions, replication, transcription, and reparation. Peptides can regulate the status of DNA methylation, which is an epigenetic mechanism for the activation or repression of genes in both the normal condition, as well as in cases of pathology and senescence’.[4]

Immunomodulators of the Immune System

Chonluten regulates the immune system and stimulates or suppresses it to respond to diseases. 

Chonluten mechanisms of action are mediated by many genes, including heat shock protein, gene HSP70, SOD, c-Fos, antioxidative system genes, and TNF-alpha. The regulation of these genes results in anti-inflammatory effects, particularly c-Fos—a powerful protein bioregulator of cell differentiation, survival, and proliferation that is activated in response to hypoxia and cellular damage. Although c-Fos can induce the growth of new blood vessels and cell proliferation at the local level in response to an injury, progressive expression can result in thickened bronchial mucosa and even cancer.[2] Chonluten’s ability to regulate c-Fos allows it to identify pathophysiological changes in COPD and asthma.

Stimulation of Anaerobic Activity

Peptides have a tremendous role in sports nutrition:

Studies have confirmed that several bioactive peptides elicit strongly upregulating effects on muscle protein synthesis or increase muscular strength and recovery. This is of special interest for sports, where large forces against an object or opponent (e.g., combat sports) are needed. Interestingly, recent discussions in the scientific community address the fact that these peptides may also be helpful for reducing injuries and accelerating return-to-sport. Besides positive effects on strength and recovery, recent investigations found that hydrolyzed proteins might also influence endurance performance and metabolism.’[6]

In athletes, Chonluten has been proven to increase energy levels and support intense training sessions, thereby increasing overall performance. As it is anti-inflammatory, it relieves without side effects to respiratory distress syndrome. 

Chonluten’s Role in COVID-19

According to pandemic research, Chonluten is effective for treating Covid-19 by inhibiting virus proteins and restoring homeostasis, and it causes no side effects.[7] Chonluten is effective in restoring lung capacity in Covid-19 patients after long periods of artificial ventilation used as a breathing treatment. Furthermore, Chonluten has similar effects to Bronchogen in treating bronchopulmonary pathology. Chonluten has a synergistic effect, increasing the efficacy of standard therapies in chronic bronchitis with an asthmatic component and a stress-protective product. With its outcome of improving physical performance and organismal function in hypoxia, Chonluten has become a full auxiliary in the collective fight against Covid-19.

Summary

Chonluten is a peptide bioregulator that modulates gene expression and can influence anti-inflammatory and antioxidant effects. It is active in the lung, but its functions extend to other vital organs such as the GI tract.

Chonluten has minimal to no side effects, with limited oral and excellent subcutaneous bioavailability. 

Chonluten is available for educational and scientific purposes, not for human consumption. Only purchase Chonluten if you are a licensed researcher.

References

  1. Avolio F, Martinotti S, Khavinson VK, Esposito JE, Giambuzzi G, Marino A, Mironova E, Pulcini R, Robuffo I, Bologna G, Simeone P, Lanuti P, Guarnieri S, Trofimova S, Procopio AD, Toniato E. Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci. 2022 Mar 25;23(7):3607
  2. V. K. Khavinson, N. S. Lin’kova, A. V. Dudkov, V. O. Polyakova, and I. M. Kvetnoi, “Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins,” Bull. Exp. Biol. Med., vol. 152, no. 5, pp. 615–618, Mar. 2012, doi: 10.1007/s10517-012-1590-2
  3. https://pubchem.ncbi.nlm.nih.gov/compound/Glutamyl-aspartyl-glycine
  4. Khavinson VK, Popovich IG, Linkova NS, Mironova ES, Ilina AR. Peptide Regulation of Gene Expression: A Systematic Review. Molecules. 2021 Nov 22;26(22):7053
  5. Khavinson VK, Lin’kova NS, Tarnovskaya SI. Short Peptides Regulate Gene Expression. Bull Exp Biol Med. 2016 Dec;162(2):288-292
  6. König D, Kohl J, Jerger S, Centner C. Potential Relevance of Bioactive Peptides in Sports Nutrition. Nutrients. 2021 Nov 10;13(11):3997. DOI: 10.3390/nu13113997
  7. V. Khavinson, N. Linkova, A. Dyatlova, B. Kuznik, and R. Umnov, “Peptides: Prospects for Use in the Treatment of COVID-19,” Molecules, vol. 25, no. 19, p. 4389, Sep. 2020, DOI: 10.3390/molecules25194389

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