Vilon (20mg)

$59.00

Size: 20mg
Contents: Vilon (20mg)
Form: Lyophilized powder
Purity: >99%
SKU: P-Vilon
Availability: In Stock

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Description

What is Vilon peptide?

Vilon is a dipeptide composed of amino acids lysine and glutamic acid. It also goes by the name ‘lysglutamic acid.’[1] It is the shortest peptide known to possess therapeutic effects. Vilon is a standard ‘all-in-one’ peptide, as evidence shows this peptide improves the immune system, helps combat cancer, possesses anti-aging properties, and works on crucial organs such as the liver, heart, and kidney.

Vilon exerts its effects by working on the chromatin structure. Different DNA cells and proteins form chromatins, and when these chromatin structures combine, they form chromosomes. These chromosomes carry genomic information to different cells in the body. 

Vilon performs the following actions on chromatin[2]

  • Unrolls the chromatin structures
  • Activates ribosomal genes stimulating the synthetic process
  • Releases inactive genes 
  • Does not decondense the chromatin situated on each side of the centromere of chromosome

By performing the above actions on the chromatin, the bioregulator peptide Vilon ultimately changes the DNA structure to reactivate the genes and cells that have gone ‘silent.’ The cells become inactive due to poor immune structure or aging, which is why cells and tissues lose function over time. Vilon peptide helps recover from this and thereby improves overall human functionality.

What are the advantages of Vilon peptides? 

Like other bioregulator peptides, Vilon helps improve the immune system, especially in immunocompromised and aged people. 

Vilon activates the interleukin-2 protein in spleen cells, which is critical in maintaining the body’s immunity.[3] It stimulates the body to fight against microbial infection and foreign bodies and prevents harmful autoimmune responses. Vilon activates the white blood cells and spleen cells and naturally boosts the body to protect against autoimmune ailments. A study was conducted in 2002 with three bioregulatory peptides to study their effects on interleukin-2 mRNA synthesis in spleen cells. According to this study, “The intensity of interleukin-2 mRNA synthesis in splenocytes depended on the type, concentration, and duration of treatment with the peptides. Vilon and Epithalon were most potent, while Cortagen produced a less pronounced effect on interleukin-2 mRNA synthesis.”[3]

Furthermore, Vilon peptides also help prevent autoimmune diseases by acting on the thymus gland. The thymus gland is responsible for the proliferation of T-helper cells, and with the help of the Vilon peptide, this proliferation is further enhanced. By increasing the synthesis of these T-helper cells, which are critical in regulating the body’s immunity, the Vilon peptide further helps regulate the immune system. As per N N Sevostianiva et al., the Vilon peptide is “considered as a bioactive substance possessing immunomodulator and antiallergic activity.” [4]

Here are some additional benefits of the Vilon peptide: 

  • Vilon can help extend the average lifespan of humans. As stated above, Vilon enhances the immune system, improving physical endurance and energy levels, thereby increasing the average lifespan.[5]
  • Vilon is advised to take early rather than later in life for best results. This is because when a bioregulator like Vilon is administered in the later stages of life, it only reverses the ‘silent’ cells but can do nothing for cells already killed via apoptosis. 
  • Several studies demonstrate that Vilon peptide helps prevent the spread of carcinogenic cells in the body by not only preventing the formation of new tumors but also inhibiting existing tumors’ growth. Therefore, Vilon not only shows potential to be used as a chemotherapeutic agent but also as an adjunct to cancer prevention therapy.[6]
  • One study contradicts this potential use of Vilon as an adjunct in chemotherapy. As per this study, when used with other chemotherapeutic agents derived from platinum ions, this peptide–platinum combination turns out to be more harmful than helpful. [7] Unfortunately, since this study only considers one specific type of chemotherapeutic method, this cannot be determined whether Vilon is an effective adjunct to chemotherapy. 
  • Vilon peptide acts on gastrointestinal functionality as it enhances the working mechanism of certain enzymes in the gastrointestinal tract. By doing so, the peptide improves body resistance towards GI-specific ailments, reduces leaky bowels, and improves overall GI health. [8]
  • Acting on the small intestinal muscles, Vilon peptide ameliorates glucose accumulation and glycine absorption. This helps in maintaining the required nutrient extraction by age.[9] 
  • As mentioned earlier, Vilon acts on the thymus gland and stimulates cellular proliferation, thereby maintaining a healthy thymus. Per the research, the healthier the thymus is, the healthier we are. As people age, the functionality of the thymus decreases – however, this can be reversed with the help of the Vilon peptide. 
  • Upon administering Vilon peptide, it alters the gene expression of 36 genes in the heart. When administered with Epithalon (another potent bioregulator peptide), this number rises to 144. This demonstrates that the peptide alters genetic expression in the cardiac system, which may help improve hemodynamic properties. [10]
  • Research has shown that Vilon stimulates fibrinolysis and increases the concentration of natural anticoagulants in the body, namely antithrombin III and protein C. It also reduces insulin levels and hence regulates the metabolism of carbohydrates in the body.[11] 
  • Vilon is said to increase the permeability of mesenteric microvessels in the vascular system. As per N. Gavrisheva et al., these results indicate that “the preparation produces a potent homeostatic effect in the early period of chronic renal failure.”[12]

Are there any side effects of Vilon peptide?

While no significant side effects have been reported, research is still ongoing to establish thorough peptide safety in humans. 

Some common side effects known include:

  • Itching, burning sensations or swelling at the injection site
  • Headache or dizziness (24 hours after taking vilon)

It is also essential to refrain from using any other products in combination with Vilon, as it may interfere with their effectiveness. In addition, individuals with sensitive skin or those allergic to any of its ingredients are not encouraged to use this peptide.

Peptide availability 

The peptide has demonstrated poor pharmacokinetics, including a short half-life, quick degradation in the gastrointestinal tract, and rapid clearance from the body. This makes it extremely difficult to use the peptide as a classic drug quite yet. Currently, it is available in injectable form, which has shown improved permeability and half-life compared to the oral form.

Conclusion

Vilon is a potent bioregulatory peptide that enhances the body’s immunity, boosts energy levels, and combats age-related health issues. While it has several different modes of action, it mainly works by ‘unfolding’ the chromatin structures and altering gene expressions. 

Vilon is an excellent peptide with promising potential in the therapeutic field. However, this compound is only available for educational and research purposes and should not be consumed or used by humans.

References:

  1. National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 7010502, Lysylglutamic acid. Retrieved November 21, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/Lysylglutamic-acid 
  2. Lezhava T, Khavison V, Monaselidze J, Jokhadze T, Dvalishvili N, Bablishvili N, Barbakadze S. Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people. Biogerontology. 2004;5(2):73-9. https://pubmed.ncbi.nlm.nih.gov/15105581/ 
  3. Kazakova TB, Barabanova SV, Khavinson VKh, Glushikhina MS, Parkhomenko EP, Malinin VV, Korneva EA. In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes. Bull Exp Biol Med. 2002 Jun;133(6):614-6. https://pubmed.ncbi.nlm.nih.gov/12447482/ 
  4. Sevostianova NN, Linkova NS, Polyakova VO, Chervyakova NA, Kostylev AV, Durnova AO, Kvetnoy IM, Abdulragimov RI, Khavinson VH. Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells. Bull Exp Biol Med. 2013 Feb;154(4):562-5. English, Russian. https://pubmed.ncbi.nlm.nih.gov/23486604/ 
  5. Khavinson VK, Anisimov VN, Zavarzina NY, Zabezhinskii MA, Zimina OA, Popovich IG, Shtylik AV, Malinin VV, Morozov VG. Effect of vilon on biological age and lifespan in mice. Bull Exp Biol Med. 2000 Jul;130(7):687-90. DOI: 10.1007/BF02682106. PMID: 11140587. https://pubmed.ncbi.nlm.nih.gov/11140587/ 
  6. Khavinson VKh, Anisimov VN. A synthetic dipeptide vilon (L-Lys-L-Glu) inhibits the growth of spontaneous tumors and increases the life span of mice. Dokl Biol Sci. 2000 May-Jun;372:261-3. PMID: 10944717. https://pubmed.ncbi.nlm.nih.gov/10944717/ 
  7. Barykina OP, Iuzhakov VV, Chalisova NI, Kvetnoĭ IM, Konovalov SS. Sochetannoe vliianie vilona i tsiklofosfana na transplanty opukholeĭ i éksplantaty limfoidnoĭ tkani mysheĭ i krys raznogo vozrasta [Combined effect of vilon and cyclophosphane on tumor transplants and lymphoid tissue explants in mice and rats of various age]. Adv Gerontol. 2003;12:128-31. Russian. PMID: 14743610. https://pubmed.ncbi.nlm.nih.gov/14743610/ 
  8. Khavinson VKh, Timofeeva NM, Malinin VV, Cordova LA, Nikitina AA. Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats. Bull Exp Biol Med. 2002 Dec;134(6):562-4. https://pubmed.ncbi.nlm.nih.gov/12660839/ 
  9. Khavinson VKh, Egorova VV, Timofeeva NM, Malinin VV, Cordova LA, Gromova LV. Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats. Bull Exp Biol Med. 2002 May;133(5):494-6. https://pubmed.ncbi.nlm.nih.gov/12420071/ 
  10. Anisimov SV, Bokheler KR, Khavinson VKh, Anisimov VN. Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology. Bull Exp Biol Med. 2002 Mar;133(3):293-9. https://pubmed.ncbi.nlm.nih.gov/12360356/ 
  11. Kuznik BI, Isakova NV, Kliuchereva NN, Maleeva NV, Pinelis IS. [Effect of vilon on the immunity status and coagulation hemostasis in patients of different age with diabetes mellitus]. Adv Gerontol. 2007;20(2):106-15. Russian. PMID: 18306698. https://pubmed.ncbi.nlm.nih.gov/18306698/ 
  12. Gavrisheva NA, Malinin VV, Ses TP, Kozlov KL, Panchenko AV, Titkov AY. Effect of peptide Vilon on the content of transforming growth factor-beta and permeability of microvessels during experimental chronic renal failure. Bull Exp Biol Med. 2005 Jan;139(1):24-6. DOI: 10.1007/s10517-005-0202-9. PMID: 16142267. https://pubmed.ncbi.nlm.nih.gov/16142267/

NOTE: These products are intended for laboratory research use only. Vilon for sale (20mg) is not intended for personal use. Please review and adhere to our Terms and Conditions before ordering.